D-E-A-D protein family of putative RNA helicases
نویسندگان
چکیده
منابع مشابه
Protein displacement by DExH/D "RNA helicases" without duplex unwinding.
Members of the DExH/D superfamily of nucleic acid-activated nucleotide triphosphatases are essential for virtually all aspects of RNA metabolism, including pre-messenger RNA splicing, RNA interference, translation, and nucleocytoplasmic trafficking. Physiological substrates for these enzymes are thought to be regions of double-stranded RNA, because several DExH/D proteins catalyze strand separa...
متن کاملRemodeling of ribonucleoprotein complexes with DExH/D RNA helicases
The DExH/D protein family is the largest group of enzymes in eukaryotic RNA metabolism. DExH/D proteins are mainly known for their ability to unwind RNA duplexes in an ATP-dependent fashion. However, it has become clear in recent years that these DExH/D RNA helicases are also involved in the ATP-dependent remodeling of RNA-protein complexes. Here we review recent studies that highlight physiolo...
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H invasive pancreatic tumors are often recognized in late stages due to a lack of clear symptoms and pose major challenges for treatment and disease management. Broad-band Protein Kinase D (PKD) inhibitors have recently been proposed as additional treatment option for this disease. PKDs are implicated in the control of cancer cell motility, angiogenesis, proliferation and metastasis. In particu...
متن کاملA family with D-D translocation.
Balanced D/D translocation carriers appear to be normal in most instances (Court-Brown et al., 1966; Giannelli and Howlett, 1966). In some cases, however, a variety ofcongenital malformations has been reported, such as Klinefelter's syndrome (Lejeune, Turpin, and Decourt, 1960), little secondary sex development (Walker and Harris, 1962), malformation of the spine (de Grouchy et al., 1963), arre...
متن کاملSURVEY AND SUMMARY Remodeling of ribonucleoprotein complexes with DExH/D RNA helicases
The DExH/D protein family is the largest group of enzymes in eukaryotic RNA metabolism. DExH/D proteins are mainly known for their ability to unwind RNA duplexes in an ATP-dependent fashion. However, it has become clear in recent years that these DExH/D RNA helicases are also involved in the ATP-dependent remodeling of RNA–protein complexes. Here we review recent studies that highlight physiolo...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 1992
ISSN: 0950-382X
DOI: 10.1111/j.1365-2958.1992.tb01470.x